Regulation of squid visual phospholipase C by activated G-protein alpha.

  title={Regulation of squid visual phospholipase C by activated G-protein alpha.},
  author={T. Suzuki and K. Narita and Akihisa Terakita and Eiji Takai and Kazuo Nagai and Yuji Kito and Yasuo Tsukahara},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  volume={122 3},
Phospholipase C (PLC) is the key enzyme in the phototransduction cascade of invertebrate rhabdomeric photoreceptors. In addition to 130 kDa PLC, a 95 kDa protein recognized by antibody against the catalytic site of PLC was found in the squid retina. The PLC-like 95 kDa protein (95 kDa PLC) was produced from 130 kDa PLC by an intrinsic protease in the presence of calcium. The 130 kDa PLC was stimulated by the active form of Gq-class G-protein alpha (Gq alpha), but the 95 kDa PLC was not… CONTINUE READING

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