Regulation of spiramycin synthesis in Streptomyces ambofaciens: effects of glucose and inorganic phosphate

  title={Regulation of spiramycin synthesis in Streptomyces ambofaciens: effects of glucose and inorganic phosphate},
  author={A. Loun{\`e}s and A. Lebrihi and C. Benslimane and G. Lefebvre and P. Germain},
  journal={Applied Microbiology and Biotechnology},
  • A. Lounès, A. Lebrihi, +2 authors P. Germain
  • Published 2009
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
  • The production of the 16-membered macrolide antibiotic, spiramycin, in Streptomyces ambofaciens is inhibited by glucose, 2-deoxyglucose and inorganic phosphate. The role of intracellular ATP content and phosphorylated metabolites as common regulating signals of both glucose and phosphate inhibitory effects is discussed. Two enzymatic targets of the effect of phosphate on spiramycin biosynthesis were studied. Valine dehydrogenase, the first enzyme of valine catabolism (supplier of aglycone… CONTINUE READING
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