Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines.

@article{Li1995RegulationOS,
  title={Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines.},
  author={H. Li and Mason W Freeman and Peter Libby},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={95 1},
  pages={
          122-33
        }
}
Scavenger receptor (ScR)-mediated uptake of modified lipoproteins may contribute to the transformation of smooth muscle cells into lipid-laden foam cells during atherogenesis. This study examined the in vivo expression of ScRs in aortas, with or without balloon injury, taken from hypercholesterolemic or normocholesterolemic rabbits. Numerous intimal cells in the rabbit aortic lesions expressed ScRs as detected by immunocytochemical staining with a goat anti-rabbit ScR antibody. Single… 
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Expression of the novel scavenger receptor SR-PSOX in cultured aortic smooth muscle cells and umbilical endothelial cells.
TLDR
expression of the novel scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX) in lipid-laden macrophages accumulated in the intima of human atherosclerotic lesions is demonstrated and the potential regulation of SR- PSOX by pro-inflammatory cytokines is discussed.
Effect of Human Scavenger Receptor Class A Overexpression in Bone Marrow–Derived Cells on Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice
TLDR
It is suggested that the reduction in VLDL cholesterol levels is due to increased clearance of modified lipoproteins by the overexpressed MSR1 in Kupffer cells of the liver, thereby protecting the arterial wall against the proatherogenic action of modified cholesterol.
Class A Scavenger Receptor Up-regulation in Smooth Muscle Cells by Oxidized Low Density Lipoprotein*
TLDR
It is shown that coincubation of SMC with macrophages or oxidized low density lipoproteins from macrophage-conditioned medium activates these same regulatory pathways and stimulates SR-A expression and suggests that increased vascular oxidative stress may contribute to the formation of both SMC and Macrophage foam cells.
Pathways of smooth muscle foam cell formation in atherosclerosis
TLDR
SMCs contribute significantly to the foam cell population in atherosclerosis, and identification of key mechanisms of SMC foam cell formation will help drive new therapeutics to reduce cardiovascular disease.
Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins.
TLDR
A LDL-induced up-regulation of the endothelin system in coronary smooth muscle cells and in monocyte-derived macrophages is demonstrated, providing further support for a pathophysiological role of endothelins in coronary atherosclerosis and suggesting that ET-1 might be involved in mediating the atherogenic effects of LDL.
Human cytomegalovirus increases modified low density lipoprotein uptake and scavenger receptor mRNA expression in vascular smooth muscle cells.
TLDR
It is demonstrated that HCMV infection of human SMCs increases modified LDL uptake and stimulates class A SR gene (SR-A) mRNA expression and increased Ox-LDL uptake is believed to play an important role in arteriosclerosis, providing a link between H CMV infection and arteriosclerotic plaque formation.
Cytokine and growth factor regulation of murine macrophage scavenger receptor expression and function
TLDR
Morphological evidence supports an adhesion role for the MSR in primary Mφ and transfected CHO cells and prominent hepatic lipid accumulation suggests a crucial M-CSF dependent role for Kupffer cells in lipoprotein uptake, transfer to hepatocytes and biliary excretion of cholesterol.
So Much Cholesterol: the unrecognized importance of smooth muscle cells in atherosclerotic foam cell formation
Purpose of review Smooth muscle cells (SMCs) form the thickened intimal layer in atherosclerosis-prone arteries in early life, and provide the initial site for retention and uptake of atherogenic…
Macrophage-specific expression of class A scavenger receptors enhances granuloma formation in the absence of increased lipid deposition.
Class A scavenger receptors (SR-A) have several proposed functions that could impact atherosclerosis and inflammatory processes. To define the function of SR-A in vivo, we created C57BL/6 transgenic…
The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon gamma.
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