Regulation of small intestinal Na-Pi type IIb cotransporter by dietary phosphate intake.

@article{Hattenhauer1999RegulationOS,
  title={Regulation of small intestinal Na-Pi type IIb cotransporter by dietary phosphate intake.},
  author={Olaf Hattenhauer and Martin Traebert and Heini Murer and Juerg Biber},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={1999},
  volume={277 4},
  pages={G756-G762}
}
Dietary restriction of phosphate is a well-known stimulator (acting indirectly via vitamin D3) of small intestinal apical Na-Picotransport. In the present study, we document by Western blots and immunohistochemistry that, in mice, a low-Pi diet given for several days leads (in parallel to a stimulation of Na-Pi cotransport) to an increase of the abundance of the type IIb Na-Pi cotransporter in the brush-border membrane of mouse enterocytes. Similar results were also obtained by an injection of… CONTINUE READING

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