Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

@article{Civitarese2010RegulationOS,
  title={Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.},
  author={Anthony E. Civitarese and Paul S Maclean and Stacy Carling and Lyndal J. Kerr-Bayles and Ryan McMillan and Anson P Pierce and Thomas C. Becker and C{\'e}dric Moro and Jean Finlayson and Natalie R Lefort and Christopher B. Newgard and Lawrence J. Mandarino and William T. Cefalu and Ken Walder and Greg R. Collier and Matthew W. Hulver and Steven R. Smith and Eric Ravussin},
  journal={Cell metabolism},
  year={2010},
  volume={11 5},
  pages={412-26}
}
Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 (PARL ortholog) maintains the function and lifecycle of mitochondria. We examined whether variation in PARL protein content is associated with mitochondrial abnormalities and insulin… CONTINUE READING