Regulation of skeletal muscle dihydropyridine receptor gene expression by biomechanical unloading.

@article{Kandarian1992RegulationOS,
  title={Regulation of skeletal muscle dihydropyridine receptor gene expression by biomechanical unloading.},
  author={Susan C. Kandarian and Sara J O'Brien and Kremens Thomas and Lothar Schulte and Javier Lorenzo Navarro},
  journal={Journal of applied physiology},
  year={1992},
  volume={72 6},
  pages={2510-4}
}
Biomechanical unloading of the rat soleus by hindlimb unweighting is known to induce atrophy and a slow- to fast-twitch transition of skeletal muscle contractile properties, particularly in slow-twitch muscles such as the soleus. The purpose of this study was to determine whether the expression of the dihydropyridine (DHP) receptor gene is upregulated in unloaded slow-twitch soleus muscles. A rat DHP receptor cDNA was isolated by screening a random-primed cDNA lambda gt10 library from… CONTINUE READING

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