Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction.

  title={Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction.},
  author={J A Timmons and S. M. Poucher and D Constantin-Teodosiu and I A Macdonald and Paul L Greenhaff},
  journal={The American journal of physiology},
  volume={274 5 Pt 2},
Pyruvate dehydrogenase complex (PDC) activation status has been described as being central in the regulation of tissue substrate oxidation as outlined by the glucose fatty-acid cycle. In the present study we examined the effects of reduced lipolysis, with use of nicotinate, and increased PDC activation, with use of dichloroacetate (DCA), on substrate utilization during 20 min of submaximal steady-state contraction (approximately 80% of maximal O2 uptake) in canine gracilis skeletal muscle. At… CONTINUE READING
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