Regulation of signalling by microRNAs.

  title={Regulation of signalling by microRNAs.},
  author={Roi Avraham and Yosef Yarden},
  journal={Biochemical Society transactions},
  volume={40 1},
Stringent regulation of biochemical signalling pathways involves feedback and feedforward loops, which underlie robust cellular responses to external stimuli. Regulation occurs in all horizontal layers of signalling networks, primarily by proteins that mediate internalization of receptor-ligand complexes, dephosphorylation of kinases and their substrates, as well as transcriptional repression. Recent studies have unveiled the role of miRNAs (microRNAs), post-transcriptional regulators that… CONTINUE READING
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