Regulation of signal transduction through protein cysteine oxidation.

  title={Regulation of signal transduction through protein cysteine oxidation.},
  author={Janet V Cross and Dennis J. Templeton},
  journal={Antioxidants & redox signaling},
  volume={8 9-10},
The production of reactive oxygen species (ROS) accompanies many signaling events. Antioxidants and ROS scavenging enzymes in general have effects that indicate a critical role for ROS in downstream signaling, but a mechanistic understanding of the contribution of ROS as second messengers is incomplete. Here, the role of reactive oxygen species in cell signaling is discussed, emphasizing the ability of ROS to directly modify signaling proteins through thiol oxidation. Examples are provided of… CONTINUE READING