Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants.

@article{Chen1999RegulationOS,
  title={Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants.},
  author={Guowei Chen and K A Hasanat and Joseph M Bebchuk and Gregory J. Moore and Debra A. Glitz and Husseini K. Manji},
  journal={Psychosomatic medicine},
  year={1999},
  volume={61 5},
  pages={
          599-617
        }
}
OBJECTIVE To determine whether the currently available evidence supports the hypothesis that antidepressants and mood stabilizers may bring about some of their long-term therapeutic effects by regulating signal transduction pathways and gene expression in the central nervous system. METHODS To address this question, we reviewed the evidence showing that chronic administration of antidepressants and mood stabilizers involves alterations in signaling pathways and gene expression in the central… CONTINUE READING

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