Regulation of signal transduction by protein targeting: the case for CaMKII.

@article{Bayer2001RegulationOS,
  title={Regulation of signal transduction by protein targeting: the case for CaMKII.},
  author={K. Ulrich Bayer and Howard F Schulman},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 5},
  pages={917-23}
}
Protein targeting is increasingly being recognized as a mechanism to ensure speed and specificity of intracellular signal transduction in a variety of biological systems. Conceptually, this is of particular importance for second-messenger-regulated protein kinases with a broad spectrum of substrates, such as the serine/threonine protein kinases PKA, PKC, and CaMKII (cyclic-AMP-dependent protein kinase, Ca(2+)-phospholipid-dependent protein kinase, and Ca(2+)/calmodulin-dependent protein kinase… CONTINUE READING
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