Regulation of sialomucin complex/Muc4 in the female rat reproductive tract.

Sialomucin complex (SMC/rat Muc4) is a heterodimeric glycoprotein complex composed of an anti-adhesive mucin subunit ascites sialoglycoprotein (ASGP)-1 and a transmembrane subunit ASGP-2. SMC expression is tightly regulated in the uterus, and its expression appears to block blastocyst implantation. Expression is controlled by steroid hormone levels in the… CONTINUE READING