Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.

@article{Berg1996RegulationOS,
  title={Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide.},
  author={Timo K van den Berg and Irma van Die and Chantal Renardel de Lavalette and Ed A. D{\"o}pp and Lemoene Smit and Peter H van der Meide and Fred J. H. Tilders and Paul R. Crocker and Christine D. Dijkstra},
  journal={Journal of immunology},
  year={1996},
  volume={157 7},
  pages={
          3130-8
        }
}
Sialoadhesin is a macrophage-restricted member of the Ig superfamily that mediates adhesion with lymphoid and myeloid cells. It is expressed on a subpopulation of macrophages in lymphoid tissues and in chronic inflammation (e.g., during autoimmune diseases). We have studied the regulation of sialoadhesin expression in vitro and show that glucocorticoids (GC) induce sialoadhesin expression on freshly isolated rat macrophages and the rat macrophage cell line R2. The cytokines IFN-beta, IFN-gamma… CONTINUE READING
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