Regulation of serum amyloid A protein expression during the acute-phase response.

@article{Jensen1998RegulationOS,
  title={Regulation of serum amyloid A protein expression during the acute-phase response.},
  author={Liselotte E Jensen and Alexander S. Whitehead},
  journal={The Biochemical journal},
  year={1998},
  volume={334 ( Pt 3)},
  pages={489-503}
}
The acute-phase (AP) serum amyloid A proteins (A-SAA) are multifunctional apolipoproteins which are involved in cholesterol transport and metabolism, and in modulating numerous immunological responses during inflammation and the AP response to infection, trauma or stress. During the AP response the hepatic biosynthesis of A-SAA is up-regulated by pro-inflammatory cytokines, and circulating concentrations can increase by up to 1000-fold. Chronically elevated A-SAA concentrations are a… CONTINUE READING
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