Regulation of serotonin 1B receptor by glycogen synthase kinase-3.

  title={Regulation of serotonin 1B receptor by glycogen synthase kinase-3.},
  author={Ligong Chen and Gregory D. Salinas and Xiaohua Li},
  journal={Molecular pharmacology},
  volume={76 6},
In response to 5-hydroxytryptamine (5-HT), the type 1 serotonin receptors (5-HT1Rs) preferentially couple to the inhibitory G protein and elicit many physiological and behavioral processes. However, their regulation by intracellular protein kinases has not been fully investigated. In this study, we identified that glycogen synthase kinase-3 (GSK3) differentially regulates 5-HT1Rs. In receptor-expressing cells and brain slices, activation of both 5-HT1AR and 5-HT1BR reduced forskolin-stimulated… CONTINUE READING
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