Regulation of serine racemase activity by amino acids.

@article{Dunlop2005RegulationOS,
  title={Regulation of serine racemase activity by amino acids.},
  author={David S. Dunlop and Amos Neidle},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={133 2},
  pages={
          208-14
        }
}
The effects of various amino acids on the activity of serine racemase, purified from mouse brain, were examined. Those acting as inhibitors included compounds with electron withdrawing groups on the beta-carbon of alanine (beta-halo-alanines and L-serine-O-sulfate), which can act as enzyme-activated inhibitors, and compounds containing beta-SH groups (cysteine and homocysteine) which react with enzyme-bound pyridoxal phosphate to form thiazolidine derivatives. Glycine and a series of… CONTINUE READING

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