Regulation of selective protein degradation in the endoplasmic reticulum by redox potential.

@article{Young1993RegulationOS,
  title={Regulation of selective protein degradation in the endoplasmic reticulum by redox potential.},
  author={James Lee Young and Lawrence P Kane and Mark Exley and Thomas M. Wileman},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 26},
  pages={19810-8}
}
Recent studies show that the endoplasmic reticulum (ER) contains proteases, but it is not understood how these enzymes are regulated. In this report we study the selective ER degradation of the subunits (alpha beta gamma delta epsilon zeta) of the T-cell antigen receptor (TCR). When analyzed in vivo, unassembled subunits of the TCR fail to reach the Golgi apparatus and show a differential sensitivity to degradation after synthesis. The alpha, beta, and delta subunits are degraded rapidly, while… CONTINUE READING
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