Regulation of scleral cell contraction by transforming growth factor-beta and stress: competing roles in myopic eye growth.

@article{Jobling2009RegulationOS,
  title={Regulation of scleral cell contraction by transforming growth factor-beta and stress: competing roles in myopic eye growth.},
  author={Andrew I Jobling and Angus Gentle and Ravikanth Metlapally and Bryan J McGowan and Neville A. Mcbrien},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 4},
  pages={
          2072-9
        }
}
Reduced extracellular matrix accumulation in the sclera of myopic eyes leads to increased ocular extensibility and is related to reduced levels of scleral transforming growth factor-beta (TGF-beta). The current study investigated the impact of this extracellular environment on scleral cell phenotype and cellular biomechanical characteristics. Scleral cell phenotype was investigated in vivo in a mammalian model of myopia using the myofibroblast marker, alpha-smooth muscle actin (alpha-SMA). In… CONTINUE READING
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Scleral Cell Phenotype Regulation and Myopic Eye Growth

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