Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐ and antiinflammatory stimuli

@article{Buechler2000RegulationOS,
  title={Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro‐ and antiinflammatory stimuli},
  author={Christa Buechler and Mirko Ritter and Evelyn Orso and Thomas Langmann and Jochen Klucken and Gerd Schmitz},
  journal={Journal of Leukocyte Biology},
  year={2000},
  volume={67}
}
Key ResultCD163, also referred to as M130, a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage. In freshly isolated monocytes the CD14bright CD16+ monocyte subset revealed the highest expression of CD163 among all monocyte subsets. CD163 mRNA and protein expression is up-regulated during macrophage colony-stimulating factor (M-CSF)-dependent phagocytic differentiation of human blood monocytes.
CD163-L1 Is an Endocytic Macrophage Protein Strongly Regulated by Mediators in the Inflammatory Response
TLDR
CD163-L1 exhibits similarity to CD163 in terms of structure and regulated expression in cultured monocytes but shows clear differences compared with the known CD163 ligand preferences and expression pattern in the pool of tissue macrophages.
Endotoxin induces rapid metalloproteinase‐mediated shedding followed by up‐regulation of the monocyte hemoglobin scavenger receptor CD163
TLDR
It is shown that CD163 is rapidly mobilized in response to bacterial endotoxin, and studies using the inhibitor TAPI‐0 indicate that a metalloproteinase is responsible for LPS‐mediated shedding of CD163.
CD163: a regulated hemoglobin scavenger receptor with a role in the anti‐inflammatory response
TLDR
Recent data indicate that solubleCD163 may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions and a role for soluble CD163 in immune suppression has been proposed.
TGF‐β regulation of human macrophage scavenger receptor CD163 is Smad3‐dependent
TLDR
It is demonstrated that transforming growth factor‐β markedly reduces expression of CD163, a macrophage‐specific member of the scavenger receptor cysteine‐rich family, and this results define a novel function for TGF‐β and implicate an important role for CD163 in the host response to inflammation.
The Scavenger Receptor CD163: Regulation, Promoter Structure and Genomic Organization
TLDR
The genomic organization of the CD163 gene is analyzed and it is demonstrated that these isoforms result from alternative splicing, which may help to understand the complete function of CD163.
M2 differentiation of MonoMac‐1 cell line induced by M‐CSF and glucocorticoid pathways
TLDR
The process used to induce CD16 expression in this cell type will be useful for screening and identification of drug candidates potentially useful for the treatment of diseases where the etiology involves the expansion of the CD16+ monocytes subset or the accumulation of CD163+ tissue macrophages.
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
TLDR
Mechanistic studies reveal that CD4+CD25+CD127lowFoxp3+ Tregs produce IL-10, IL-4, and IL-13 and that these cytokines are the critical factors involved in the suppression of the proinflammatory cytokine response.
SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF‐1R‐dependent signaling
TLDR
It is suggested that SAA can promote a distinct CD11chigh CD11bhigh macrophage phenotype, and targeting this population may provide a novel approach to treating chronic inflammatory conditions associated with persistent SAA expression.
CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo
TLDR
Overall, the results suggest that CD163L1 expression is associated with tissue‐resident Mφs with an anti‐inflammatory or anergic phenotype and that CLEC5A+ M φs exhibit TNF‐producing ability and might display a proinflammatory effect.
...
...

References

SHOWING 1-10 OF 50 REFERENCES
Differences in the state of differentiation of THP‐1 cells induced by phorbol ester and 1,25‐dihydroxyvitamin D3
TLDR
The results indicate that phorbol ester and the active metabolite of vitamin D induce different signal pathways, which might result in different achievement of differentiation.
Dissection of macrophage differentiation pathways in cutaneous macrophage disorders and in vitro
TLDR
MS‐1 high molecular weight protein is selectively expressed by cutaneous non‐Langerhans cell histiocytoses, and proves to be a valuable diagnostic tool for these diseases, and Interferon‐y (and less so tumor necrosis factor‐ex) inhibit expression of all three antigens in cultured human monocytes/macrophages.
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
TLDR
Cultured DCs are as efficient as antigen-specific B cells in presenting tetanus toxoid (TT) to specific T cell clones and their efficiency of antigen presentation can be further enhanced by specific antibodies via FcR- mediated antigen uptake.
The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages
TLDR
Comparison with alveolar macrophages revealed that these cells are similar to the CD14+/CD16+ monocytes in that they show low levels of CD14 and strong expression of CD16, and also exhibit higher levels of class II and lower levels ofCD11b and CD33 when compared to the regular CD14++ blood monocytes.
Stat1 combines signals derived from IFN‐γ and LPS receptors during macrophage activation
TLDR
The data suggest Stat1 to be a convergence point for immunological stimuli in a macrophage proinflammatory response and serine kinase may recognize tyrosine‐phosphorylated Stat1 preferentially in the course of an IFN‐γ response.
Establishment of a human cell line (mono mac 6) with characteristics of mature monocytes
TLDR
Monocytic cell line Mono Mac 6 appears to be the only one of the cell lines studied to constitutively express phenotypic and functional features of mature monocytes.
Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia.
TLDR
Estimation of circulating blood monocyte subpopulations as potential cellular markers of systemic immunological abnormalities in hypercholesterolemia and Expression of the variant activation antigen CD45RA by peripheral blood mononuclear phagocytes showed a positive correlation to plasma levels of the atherogenic lipoproteins low density lipoprotein and lipop Protein(a).
Establishment and characterization of a human acute monocytic leukemia cell line (THP‐1)
TLDR
Results indicate that THP‐1 is a leukemic cell line with distinct monocytic markers, and the ability to restore T‐lymphocyte response to Con A.
Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10.
TLDR
The results indicate that in human monocytes, the mechanism(s) of IL-10 suppression of both IL-12 p40 and IL- 12 p35 genes is primarily seen at the transcriptional level, and that the induction of the IL-11 p35 and p 35 genes have different requirements for de novo protein synthesis.
...
...