Regulation of ribosomal protein mRNA content and translation in growth-stimulated mouse fibroblasts.

@article{Geyer1982RegulationOR,
  title={Regulation of ribosomal protein mRNA content and translation in growth-stimulated mouse fibroblasts.},
  author={Pamela K Geyer and Oded Meyuhas and R. P. Perry and Lee F. Johnson},
  journal={Molecular and cellular biology},
  year={1982},
  volume={2 6},
  pages={685-93}
}
When resting (G0) mouse 3T6 fibroblasts are serum stimulated to reenter the cell cycle, the rates of synthesis of rRNA and ribosomal proteins increase, resulting in an increase in ribosome content beginning about 6 h after stimulation. In this study, we monitored the content, metabolism, and translation of ribosomal protein mRNA (rp mRNA) in resting, exponentially growing, and serum-stimulated 3T6 cells. Cloned cDNAs for seven rp mRNAs were used in DNA-excess filter hybridization studies to… CONTINUE READING

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