Regulation of ribonuclease III processing by double-helical sequence antideterminants.

@article{Zhang1997RegulationOR,
  title={Regulation of ribonuclease III processing by double-helical sequence antideterminants.},
  author={Kaixia Zhang and Allen W. Nicholson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 25},
  pages={13437-41}
}
The double helix is a ubiquitous feature of RNA molecules and provides a target for nucleases involved in RNA maturation and decay. Escherichia coli ribonuclease III participates in maturation and decay pathways by site-specifically cleaving double-helical structures in cellular and viral RNAs. The site of cleavage can determine RNA functional activity and half-life and is specified in part by local tertiary structure elements such as internal loops. The involvement of base pair sequence in… CONTINUE READING