Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos

@article{Dale1996RegulationOR,
  title={Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos},
  author={Nicholas Dale and Deborah Gilday},
  journal={Nature},
  year={1996},
  volume={383},
  pages={259-263}
}
MANY rhythmic motor behaviours, including swimming1, walking2, scratching3, swallowing4, micturition5 and sexual climax6, are episodic: even in the absence of sensory inputs they exhibit a gradual run-down in frequency before spontaneously terminating. We have investigated whether the purinergic transmitters, ATP and adenosine, control run-down of swimming in the Xenopus embryo7. By using specific agonists and antagonists for the purinergic receptors, we have shown that ATP (or a related… CONTINUE READING
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