Cyclooxygenase-2 (COX-2) is involved in kidney morphogenesis and is transiently elevated in the immature kidney. In adult rats, renal cortical COX-2 expression is tonically suppressed by mineralocorticoids (MC) and glucocorticoids (GC) and induced by chronic salt restriction. Young rats have low levels of GC and are in a state of relative volume depletion… (More)
Fig. 6. A: effects of dietary salt intake on cortical COX-2 expression in weanling rats. Rats weaned at P19 were treated with different dietary salt diets for 1 wk. Low-salt (LS) diet (lanes 3 and 4) induced and high-salt (HS) diet (lanes 5 and 6) inhibited cortical COX-2 expression. B: effects of saline subcutaneous injection on renal cortical COX-2 expression in weanling rats. Weanling rats were injected subcutaneously with sterile normal saline at a dose of 3.2 mg g 1 day 1 for a week (P19-P26). Salt supplementation by saline subcutaneous injection effectively suppressed cortical COX-2 expression as well as HS diet in the weanling rats.