Regulation of renal cell organic osmolyte transport by tonicity.

@article{Handler1993RegulationOR,
  title={Regulation of renal cell organic osmolyte transport by tonicity.},
  author={Joseph S. Handler and Hyug Moo Kwon},
  journal={The American journal of physiology},
  year={1993},
  volume={265 6 Pt 1},
  pages={C1449-55}
}
Madin-Darby canine kidney cells accumulate several nonperturbing organic osmolytes when cultured in a hypertonic medium. Myo-inositol, betaine, and taurine are accumulated secondary to an increase in uptake, the first coupled to sodium entry, the latter two coupled to sodium and chloride entry. The transport rates increase as the result of an increase in maximum velocity for each cotransporter, with peak activity 24 h after the increase in tonicity. The cDNA for each cotransporter has been… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Downregulation of the osmolyte transporters SMIT and BGT1 by AMP-activated protein kinase.

Biochemical and biophysical research communications • 2012
View 4 Excerpts
Highly Influenced

Upregulation of Na+,Cl(-)-coupled betaine/γ-amino-butyric acid transporter BGT1 by Tau tubulin kinase 2.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2013

Down-regulation of the myoinositol transporter SMIT by JAK2.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2012

Similar Papers

Loading similar papers…