Regulation of release of somatotropin from in vitro cultures of bovine and porcine pituitary cells.

@article{Glenn1986RegulationOR,
  title={Regulation of release of somatotropin from in vitro cultures of bovine and porcine pituitary cells.},
  author={Kevin C Glenn},
  journal={Endocrinology},
  year={1986},
  volume={118 6},
  pages={
          2450-7
        }
}
Bovine and human GH releasing factors (GHRF), in concentrations ranging from 10 pM to 10 nM, stimulated GH release from cultured bovine and porcine anterior pituitary cells. Agents that increase intracellular cAMP levels (e.g. isobutylmethylxanthine and 8-bromo-cAMP) also stimulated bovine and porcine GH release. Somatostatin, in doses ranging from 1-100 nM, inhibited both basal and GHRF-stimulated GH release from the bovine pituitary cultures, and 100 nM somatostatin inhibited GHRF-stimulated… CONTINUE READING