Regulation of red blood cell filterability by Ca2+ influx and cAMP-mediated signaling pathways.

@article{Oonishi1997RegulationOR,
  title={Regulation of red blood cell filterability by Ca2+ influx and cAMP-mediated signaling pathways.},
  author={Tadahiro Oonishi and Kanako Sakashita and Nobuhiro Uyesaka},
  journal={The American journal of physiology},
  year={1997},
  volume={273 6},
  pages={
          C1828-34
        }
}
To investigate the mechanism of the regulation of human red blood cell deformability, we examined the deformability under mechanical stress. Washed human red blood cells were rapidly injected through a fine needle, and their filterability was measured using a nickel mesh filter. The decrease in filterability showed a V-shaped curve depending on the extracellular Ca2+ concentration; the maximum decrease was achieved at approximately 50 muM. The decreased filterability was accompanied by no… CONTINUE READING

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