Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.

@article{Su2015RegulationOR,
  title={Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.},
  author={Xiaofeng A. Su and Vincent Dion and Susan M. Gasser and Catherine H Freudenreich},
  journal={Genes & development},
  year={2015},
  volume={29 10},
  pages={1006-17}
}
Secondary structure-forming DNA sequences such as CAG repeats interfere with replication and repair, provoking fork stalling, chromosome fragility, and recombination. In budding yeast, we found that expanded CAG repeats are more likely than unexpanded repeats to localize to the nuclear periphery. This positioning is transient, occurs in late S phase, requires replication, and is associated with decreased subnuclear mobility of the locus. In contrast to persistent double-stranded breaks… CONTINUE READING

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