Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammals.

@article{Wang2000RegulationOR,
  title={Regulation of rat magnocellular neurosecretory system by D-aspartate: evidence for biological role(s) of a naturally occurring free D-amino acid in mammals.},
  author={Hui-Yun Wang and Herman Wolosker and Jonathan Pevsner and Solomon H Snyder and Dennis J Selkoe},
  journal={The Journal of endocrinology},
  year={2000},
  volume={167 2},
  pages={247-52}
}
Little evidence is available for the physiological function of D-amino acids in species other than bacteria. Here we demonstrate that naturally occurring freed -aspartate (D-Asp) is present in all magnocellular neurons of rat hypothalamus. The levels of this naturally occurring D-amino acid were elevated during lactation and returned to normal thereafter in the magnocellular neurosecretory system, which produces oxytocin, a hormone responsible for milk ejection during lactation. Intraperitoneal… CONTINUE READING
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