Regulation of rat dopamine β-hydroxylase gene transcription by early growth response gene 1 (Egr1)

@article{Cheng2008RegulationOR,
  title={Regulation of rat dopamine β-hydroxylase gene transcription by early growth response gene 1 (Egr1)},
  author={Shu-Yuan Cheng and Lidia I. Serova and D. V. Glazkova and Esther L. Sabban},
  journal={Brain Research},
  year={2008},
  volume={1193},
  pages={1-11}
}
Egr1, a transcription factor rapidly induced by various stimuli including stress, can elevate transcription of genes for the catecholamine biosynthetic enzymes TH and PNMT. To examine if Egr1 also regulates dopamine beta-hydroxylase (DBH) gene expression, PC12 cells were transfected with expression vector for full length or truncated inactive Egr1 and various DBH promoter-driven luciferase constructs. While Egr1 elevated TH promoter activity, DBH promoter activity was reduced. The reduction… CONTINUE READING
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