Regulation of radial glial survival by signals from the meninges.

  title={Regulation of radial glial survival by signals from the meninges.},
  author={Randor Radakovits and Cl{\'a}udia M{\'a}rcia Santos Barros and Richard Belvindrah and Bruce L. Patton and Ulrich Mueller},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 24},
Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also control the function of RGCs more directly. Here, we show that RGC numbers and cortical size are reduced in mice lacking beta1 integrins in RGCs. TUNEL stainings and time-lapse video recordings demonstrate that beta1-deficient RGCs processes detach from the meningeal basement… CONTINUE READING


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