Regulation of rDNA Transcription by Proto-Oncogene PELP1

  title={Regulation of rDNA Transcription by Proto-Oncogene PELP1},
  author={Vijay Kumar Gonugunta and Binoj Chandrasekharan Nair and Rajib Rajhans and Gangadhara Reddy Sareddy and Sujit S. Nair and Ratna K Vadlamudi},
  booktitle={PloS one},
BACKGROUND Proline-, glutamic acid-, and leucine-rich protein (PELP1) is a novel nuclear receptor coregulator with a multitude of functions. PELP1 serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates as a transcriptional coregulator. Recent data suggest that PELP1 expression is deregulated in hormonal cancers, and that PELP1 functions as a proto-oncogene; however, the mechanism by which PELP1 promotes oncogenesis remains elusive… CONTINUE READING


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