Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3β.

@article{Gao2013RegulationOP,
  title={Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3β.},
  author={W. Gao and Jie Liu and Mengjie Hu and Mingfeng Huang and Sisi Cai and Zhiping Zeng and B. Lin and X. Cao and Jiebo Chen and J. Zeng and H. Zhou and X. Zhang},
  journal={Carcinogenesis},
  year={2013},
  volume={34 6},
  pages={
          1208-15
        }
}
We recently reported that an N-terminally truncated retinoid X receptor-α (tRXRα) produced in cancer cells acts to promote cancer cell growth and survival through AKT activation. However, how RXRα is cleaved and how the cleavage is regulated in cancer cells remain undefined. In this study, we demonstrated that calpain II could cleave RXRα protein in vitro, generating two truncated RXRα products. The cleavage sites in RXRα were mapped by Edman N-terminal sequencing to Gly(90)↓Ser(91) and Lys(118… Expand
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