Regulation of protein tyrosine phosphatases by reversible oxidation.

  title={Regulation of protein tyrosine phosphatases by reversible oxidation.},
  author={Arne Ostman and Jeroen Frijhoff and Asa Sandin and Frank-D. Boehmer},
  journal={Journal of biochemistry},
  volume={150 4},
Oxidation of the catalytic cysteine of protein-tyrosine phosphatases (PTP), which leads to their reversible inactivation, has emerged as an important regulatory mechanism linking cellular tyrosine phosphorylation and signalling by reactive-oxygen or -nitrogen species (ROS, RNS). This review focuses on recent findings about the involved pathways, enzymes and biochemical mechanisms. Both the general cellular redox state and extracellular ligand-stimulated ROS production can cause PTP oxidation… CONTINUE READING
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