Regulation of protein tyrosine kinase signaling by substrate degradation during brain development.

@article{Arnaud2003RegulationOP,
  title={Regulation of protein tyrosine kinase signaling by substrate degradation during brain development.},
  author={Lionel Arnaud and Bryan A. Ballif and Jonathan A Cooper},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 24},
  pages={9293-302}
}
Disabled-1 (Dab1) is a cytoplasmic adaptor protein that regulates neuronal migrations during mammalian brain development. Dab1 function in vivo depends on tyrosine phosphorylation, which is stimulated by extracellular Reelin and requires Src family kinases. Reelin signaling also negatively regulates Dab1 protein levels in vivo, and reduced Dab1 levels may be part of the mechanism that regulates neuronal migration. We have made use of mouse embryo cortical neuron cultures in which Reelin induces… CONTINUE READING

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