Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP.

@article{Luna2002RegulationOP,
  title={Regulation of protein transport from the Golgi complex to the endoplasmic reticulum by CDC42 and N-WASP.},
  author={Ana Gabriela de Luna and Olga B Matas and Jos{\'e} A Mart{\'i}nez-Men{\'a}rguez and Eug{\`e}nia 4 Mato and Juan M. Duran and Jos{\'e} Ballesta and Michael Way and Gustavo Egea},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 3},
  pages={866-79}
}
Actin is involved in the organization of the Golgi complex and Golgi-to-ER protein transport in mammalian cells. Little, however, is known about the regulation of the Golgi-associated actin cytoskeleton. We provide evidence that Cdc42, a small GTPase that regulates actin dynamics, controls Golgi-to-ER protein transport. We located GFP-Cdc42 in the lateral portions of Golgi cisternae and in COPI-coated and non-coated Golgi-associated transport intermediates. Overexpression of Cdc42 and its… CONTINUE READING