Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.

BACKGROUND & AIMS Cholecystokinin (CCK) stimulates protein synthesis in pancreatic acini at the translational level, although the signaling mechanisms involved remain uncharacterized. Two intermediates controlling translation are p70 S6 kinase and PHAS-I. We previously showed that CCK activates p70 S6K in pancreatic acini through phosphatidylinositol 3… (More)