Regulation of protein synthesis by branched-chain amino acids in vivo.

@article{Yoshizawa2004RegulationOP,
  title={Regulation of protein synthesis by branched-chain amino acids in vivo.},
  author={Fumiaki Yoshizawa},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={313 2},
  pages={417-22}
}
Recent advances in the understanding of mRNA translation have facilitated molecular studies on the regulation of protein synthesis by nutrients and the interplay between nutrients and hormonal signals. Numerous reports have established that, in skeletal muscle, the branched-chain amino acids (BCAAs) have the unique ability to initiate signal transduction pathways that modulate translation initiation. Of the BCAAs, leucine is the most potent. Oral administration of leucine to food-deprived rats… CONTINUE READING