Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy

  title={Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy},
  author={Martin U. Braun and P. Larosee and G. Simonis and Mathias M. Borst and R. Strasser},
  journal={Molecular and Cellular Biochemistry},
  • Martin U. Braun, P. Larosee, +2 authors R. Strasser
  • Published 2004
  • Medicine, Biology
  • Molecular and Cellular Biochemistry
  • Protein kinase C (PKC) is a family of at least 11 isozymes and known to play a crucial role in myocardial growth. The present study was performed to investigate whether PKC-isozymes are differentially regulated during the development of volume-overload cardiac hypertrophy. After 2, 7 and 30 days of sham or aortocaval shunt operation in male Wistar rats, PKC-activity and the expression of cardiac PKC-isozymes (PKC-α, δ and ε) were determined at the protein and at the mRNA-level in the left and… CONTINUE READING
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    Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat.
    • 182
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    Two distinct mechanisms mediate a differential regulation of protein kinase C isozymes in acute and prolonged myocardial ischemia.
    • 55
    Molecular basis of cardiac hypertrophy
    • 56