Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy

  title={Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy},
  author={Martin U. Braun and Paul Larosee and Gregor Simonis and Mathias Maximilian Borst and Ruth H. Strasser},
  journal={Molecular and Cellular Biochemistry},
Protein kinase C (PKC) is a family of at least 11 isozymes and known to play a crucial role in myocardial growth. The present study was performed to investigate whether PKC-isozymes are differentially regulated during the development of volume-overload cardiac hypertrophy. After 2, 7 and 30 days of sham or aortocaval shunt operation in male Wistar rats, PKC-activity and the expression of cardiac PKC-isozymes (PKC-α, δ and ε) were determined at the protein and at the mRNA-level in the left and… CONTINUE READING


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PKC alpha regulates the hypertrohic growth of cardiomyocytes through extracellular signalregulated kinase 1/2 (ERK 1/2)

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  • J Cell Biol
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