Regulation of protein kinase C gene expression by retinoic acid in B16 mouse melanoma cells.

@article{Rosenbaum1992RegulationOP,
  title={Regulation of protein kinase C gene expression by retinoic acid in B16 mouse melanoma cells.},
  author={Sean Rosenbaum and Richard M. Niles},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={294 1},
  pages={123-9}
}
We have previously shown that the retinoic acid (RA)-induced growth arrest and differentiation of B16 mouse melanoma cells is accompanied by a large increase in the amount and activity of protein kinase C (PKC). Since PKC is a multigene family, we investigated which isoforms were expressed in control and RA-treated B16 melanoma cells, and characterized the manner by which RA regulates PKC gene expression. We found that RA treatment of B16 cells resulted in an increase in PKC alpha mRNA… CONTINUE READING

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