Regulation of protein kinase C-epsilon and its age-dependence.

  title={Regulation of protein kinase C-epsilon and its age-dependence.},
  author={Chen Kang and Jingping Qin and Wil Osei and Keli Hu},
  journal={Biochemical and biophysical research communications},
  volume={482 4},
Protein kinase C (PKC) is an important mediator in the cardioprotection of ischemic preconditioning and has been shown to translocate to mitochondria upon activation. However, little is known about the cellular signaling underlying the translocation of PKC isoforms to mitochondria and its age-dependence. The present study aimed to explore whether adenosine-induced translocation of PKCε to mitochondria is mediated by caveolin-3 and/or adenosine A2B receptor/PI3 kinase mediated signaling, and… CONTINUE READING