Regulation of protein kinase C and role in cancer biology

  title={Regulation of protein kinase C and role in cancer biology},
  author={Gerard C. Blobe and Lina M Obeid and Yusuf A. Hannun},
  journal={Cancer and Metastasis Reviews},
Protein kinase C (PKC) is a family of closely related lipid-dependent and diacyglycerol-activated isoenzymes known to play an important role in the signal transduction pathways involved in hormone release, mitogenesis and tumor promotion. Reversible activation of PKC by the second messengers diacylglycerol and calcium is an established model for the short term regulation of PKC in the immediate events of signal transduction. PKC can also be modulated long term by changes in the levels of… CONTINUE READING
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Protein kinase C : A key factor in the regulation of tumor cell adhesion to the endothelium

  • Herbert J-M
  • Biochem Pharmacol
  • 1993

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