Regulation of protein function by glycosaminoglycans--as exemplified by chemokines.

@article{Handel2005RegulationOP,
  title={Regulation of protein function by glycosaminoglycans--as exemplified by chemokines.},
  author={Tracy M. Handel and Zaiga Johnson and Susan E Crown and Elaine K. Lau and Amanda E. I. Proudfoot},
  journal={Annual review of biochemistry},
  year={2005},
  volume={74},
  pages={385-410}
}
Immune modulators such as cytokines and growth factors exert their biological activity through high-affinity interactions with cell-surface receptors, thereby activating specific signaling pathways. However, many of these molecules also participate in low-affinity interactions with another class of molecules, referred to as proteoglycans. Proteoglycans consist of a protein core to which glycosaminoglycan (GAG) chains are attached. The GAGs are long, linear, sulfated, and highly charged… CONTINUE READING
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