Regulation of protein 4.1R interactions with membrane proteins by Ca2+ and calmodulin.

@article{Nunomura2006RegulationOP,
  title={Regulation of protein 4.1R interactions with membrane proteins by Ca2+ and calmodulin.},
  author={Wataru Nunomura and Yuichi Takakuwa},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2006},
  volume={11},
  pages={1522-39}
}
Red blood cell protein 4.1 (4.1R) is essential for maintaining erythrocyte shape and controlling membrane mechanical properties, such as deformability and stability. The importance of 4.1R has been demonstrated by the dramatic erythrocyte alterations observed in patients lacking this protein. Indeed, 4.1R null red blood cells adopt an elliptical shape and are characterized by unstable membranes. The key role of 4.1R likely results from multiple protein-protein interactions: lateral interactions… CONTINUE READING

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