Regulation of prostaglandin synthesis during differentiation of cultured mouse myeloid leukemia cells.

@article{Honma1980RegulationOP,
  title={Regulation of prostaglandin synthesis during differentiation of cultured mouse myeloid leukemia cells.},
  author={Yoshio Honma and Takashi Kasukabe and Motoo Hozumi and Yasuko Koshihara},
  journal={Journal of cellular physiology},
  year={1980},
  volume={104 3},
  pages={
          349-57
        }
}
Mouse myeloid leukemia cells (Ml) were induced to differentiate into mature macrophages and granulocytes by various inducers. The differentiated Ml cells synthesized and released prosetaglandins, whereas untreated Ml cells did not. When the cells wee prelabelled with [14C]arachidonate, the major prostaglandins released into the culture media were found to be prostaglandin E2, D2, and F2 alpha in an early stage of differentiation, but the mature cells produced predominantly prostaglandin E2. The… CONTINUE READING