Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF.

@article{Ohta2000RegulationOP,
  title={Regulation of proliferation and differentiation in spermatogonial stem cells: the role of c-kit and its ligand SCF.},
  author={Hisashi Ohta and Kentaro Yomogida and Kayoko Dohmae and Yoshitake Nishimune},
  journal={Development},
  year={2000},
  volume={127 10},
  pages={2125-31}
}
To study self-renewal and differentiation of spermatogonial stem cells, we have transplanted undifferentiated testicular germ cells of the GFP transgenic mice into seminiferous tubules of mutant mice with male sterility, such as those dysfunctioned at Steel (Sl) locus encoding the c-kit ligand or Dominant white spotting (W) locus encoding the receptor c-kit. In the seminiferous tubules of Sl/Sl(d) or Sl(17H)/Sl(17H) mice, transplanted donor germ cells proliferated and formed colonies of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 74 extracted citations

Sertoli Cells

Methods in Molecular Biology • 2018

References

Publications referenced by this paper.
Showing 1-10 of 37 references

Germline transmission of donor haplotype following spermatogonial transplantation.

Proceedings of the National Academy of Sciences of the United States of America • 1994
View 1 Excerpt
Highly Influenced

Gene-induced embryological modifications of primordial germ cells in the mouse.

The Journal of experimental zoology • 1957
View 1 Excerpt
Highly Influenced

Developmental analysis of a mutation with pleiotropic effects in the mouse

D. Bennett
J . Morph . • 1956
View 1 Excerpt
Highly Influenced

Similar Papers

Loading similar papers…