Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.

@article{Niimi2008RegulationOP,
  title={Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.},
  author={Atsuko Niimi and Stephanie E. Brown and Simone Sabbioneda and Patricia L. Kannouche and Andrew Scott and Akira Yasui and Catherine Green and A. R. Lehmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 42},
  pages={16125-30}
}
After exposure to DNA-damaging agents that block the progress of the replication fork, monoubiquitination of proliferating cell nuclear antigen (PCNA) mediates the switch from replicative to translesion synthesis DNA polymerases. We show that in human cells, PCNA is monoubiquitinated in response to methyl methanesulfonate and mitomycin C, as well as UV light, albeit with different kinetics, but not in response to bleomycin or camptothecin. Cyclobutane pyrimidine dimers are responsible for most… CONTINUE READING