Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokines.

Abstract

Previously, we reported that the transcription factor T-bet (Tbx21) regulates Th17 responses to Trypanosoma cruzi infection in an IFN-γ-independent manner. In an effort to further understand this regulation, we examined the development and plasticity of Th17 cells during T. cruzi infection. Th17 cells recovered from infected Tbx21(-/-) mice were amenable to… (More)
DOI: 10.4049/jimmunol.1103478

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