Regulation of progesterone signaling during pregnancy: implications for the use of progestins for the prevention of preterm birth.

@article{Byrns2014RegulationOP,
  title={Regulation of progesterone signaling during pregnancy: implications for the use of progestins for the prevention of preterm birth.},
  author={Michael C. Byrns},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2014},
  volume={139},
  pages={173-81}
}
Preterm birth is a major cause of neonatal morbidity and mortality. Progesterone plays a critical role in suppressing the inflammatory signals that would induce parturition prior to term. Progesterone signaling is regulated in a variety of ways during pregnancy. Endocrine production of high levels of progesterone by the placenta ensures the availability of high levels of progesterone throughout pregnancy. Paracrine regulation of progesterone metabolism in target tissues, particularly the… CONTINUE READING