Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

@article{Johnnidis2008RegulationOP,
  title={Regulation of progenitor cell proliferation and granulocyte function by microRNA-223},
  author={Jonathan B. Johnnidis and Marian H. Harris and Robert T Wheeler and Sandra Stehling-Sun and Michael H. Lam and Oktay Kirak and Thijn R Brummelkamp and Mark D Fleming and Fernando D Camargo},
  journal={Nature},
  year={2008},
  volume={451},
  pages={1125-1129}
}
MicroRNAs are abundant in animal genomes and have been predicted to have important roles in a broad range of gene expression programmes. Despite this prominence, there is a dearth of functional knowledge regarding individual mammalian microRNAs. Using a loss-of-function allele in mice, we report here that the myeloid-specific microRNA-223 (miR-223) negatively regulates progenitor proliferation and granulocyte differentiation and activation. miR-223 (also called Mirn223) mutant mice have an… CONTINUE READING
Highly Influential
This paper has highly influenced 35 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 439 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…