Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

  title={Regulation of progenitor cell proliferation and granulocyte function by microRNA-223},
  author={Jonathan B. Johnnidis and Marian H. Harris and Robert T Wheeler and Sandra Stehling-Sun and Michael H. Lam and Oktay Kirak and Thijn R Brummelkamp and Mark D Fleming and Fernando D Camargo},
MicroRNAs are abundant in animal genomes and have been predicted to have important roles in a broad range of gene expression programmes. Despite this prominence, there is a dearth of functional knowledge regarding individual mammalian microRNAs. Using a loss-of-function allele in mice, we report here that the myeloid-specific microRNA-223 (miR-223) negatively regulates progenitor proliferation and granulocyte differentiation and activation. miR-223 (also called Mirn223) mutant mice have an… CONTINUE READING
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