Regulation of proenkephalin by Fos and Jun.

@article{Sonnenberg1989RegulationOP,
  title={Regulation of proenkephalin by Fos and Jun.},
  author={J L Sonnenberg and F. Rauscher and J. I. Morgan and Tom Curran},
  journal={Science},
  year={1989},
  volume={246 4937},
  pages={1622-5}
}
Fos and Jun form a heterodimeric complex that associates with the nucleotide sequence motif known as the AP-1 binding site. Although this complex has been proposed to function as a transcriptional regulator in neurons, no specific target gene has yet been identified. Proenkephalin mRNA increased in the hippocampus during seizure just after an increase in c-fos and c-jun expression was detected. Fos-Jun complexes bound specifically to a regulatory sequence in the 5' control region of the… CONTINUE READING

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